DOWNTIME: Sunday 15th April 2018

MitoMiner will be offline on Sunday 15th of April from 11.00 GMT for a few hours to allow the Human Protein Atlas localisation data to be updated. Sorry for the inconvenience. 

DOWNTIME: Sunday 18th March 2018

MitoMiner will be offline on Sunday 18th of March from 11.00 GMT for a few hours to fix a minor bug. Sorry for the inconvenience. 

DOWNTIME: Saturday 10th February 2018

MitoMiner will be offline on Saturday 10th of February from 11:00 GMT for a few hours, to fix a couple of minor bugs. Sorry for the inconvenience. 

DOWNTIME: Thursday 9th November 2017

MitoMiner will be offline on Thursday 9th of September from 07:00 GMT for a few hours to allow the building's network connection to be upgraded. Sorry for the inconvenience.

DOWNTIME: Sunday 24th of September 2017

MitoMiner will be offline on Sunday 24th of September from 11:00 GMT for a few hours, to fix a couple of minor bugs. Sorry for any inconvenience. 

MitoMiner Updated! - September 2017

We have updated all the data sources that make up MitoMiner. Further details can be found here: http://mitominer.mrc-mbu.cam.ac.uk/release-4.0-beta/dataCategories.do

 

The biggest changes are:

 

IMPI - Integrated Mitochondrial Protein Index - Q3 2017

IMPI has had a major update - it uses more data and uses a different machine learning method (SVMs).  The final list contains 1550 genes in human (1130 known and 420 predicted). To make MitoMiner easier to use each mammalian gene is now in one of the following categories (found in the summary header):

Known mitochondrial

Predicted mitochondrial

Predicted NOT mitochondrial

Known NOT mitochondrial

Probable contaminant

Dubious gene (pseudogenes, read-throughs etc.)

 

Mitochondrial diseases

We have also added a new mitochondrial disease section that provides additional information and links to the mitochondrial disorders pages at the Washington University Neuromuscular Disease Center http://neuromuscular.wustl.edu/mitosyn.html

 

New localisation datasets

We have also added four new localisation studies, three of which include sublocation information (Matrix, IMS etc.):

 

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation.

Hung VLam SSUdeshi NDSvinkina TGuzman GMootha VKCarr SATing AY.

Elife. 2017 Apr 25;6.

PMID:28441135

 

Proteome analysis of human embryonic stem cells organelles

Shekari FNezari HLarijani MRHan CLBaharvand HChen YJSalekdeh GH.

J Proteomics. 2017 Jun 6;162:108-118

PMID: 28435121

 

Landscape of submitochondrial protein distribution.

Vögtle FNBurkhart JMGonczarowska-Jorge HKücükköse CTaskin AAKopczynski DAhrends RMossmann DSickmann AZahedi RPMeisinger C.

Nat Commun. 2017 Aug 18;8(1):290

PMID: 28819139

 

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale.

Morgenstern MStiller SBLübbert PPeikert CDDannenmaier SDrepper FWeill UHöß PFeuerstein RGebert MBohnert Mvan der Laan MSchuldiner MSchütze COeljeklaus SPfanner NWiedemann NWarscheid B.

Cell Rep. 2017 Jun 27;19(13):2836-2852

PMID: 28658629

 

Human Protein Atlas RNA tissue levels

RNA tissue levels from the Human Protein Atlas are now included in addition to the tissue antibody data

 

BioGRID

The interaction networks have been retired due to lack of use and maintenance difficulties. If you use this data please get in touch.

 

Thank you to everyone who made suggestions - your feedback makes MitoMiner better! If you have any questions or comments you can write to us at mitominer@mrc-mbu.cam.ac.uk.

DOWNTIME: Monday 18th of September 2017

MitoMiner will be offline on Monday 18th of September from 09:00 GMT to allow for a major new update. Sorry for any inconvenience. 

DOWNTIME: Saturday 29th of July 2017

MitoMiner will be unavailable from 08:00 GMT Saturday 29th of July until 15:00 GMT. This due to the power supply to the Units servers being upgraded. Sorry for any inconvenience this may cause.

DOWNTIME: Wednesday 7th of June 2017

MitoMiner will be unavailble on Wednesday 7th of June due to server upgrades. Sorry for any inconvenience. 

MitoMiner update coming soon!

In the next few weeks we will be updating all the data in MitoMiner, upgrading the underlying InterMine software and making various bug fixes. If you have any data or feature requests for this upcoming release please contact us at mitominer@mrc-mbu.cam.ac.uk 

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